I've got a site which has a 2007 content database around 165GB at present they're running out of space on the SQL server so I'm just going to advise we move them all to a new SQL Server 2008 R2 database server with ample space.
After which the customer is considering migrating to SharePoint 2010, I'm a little aprehensive about kicking off the migration on such a large content DB, but I suspect it would probably go through but just take a fairly long time.
The other option is we work on getting the size of the primary content DB down to around 100GB and attempt it then. I'll get the WFE on Server 2008 R2 and kick off an inplace upgrade and cross my fingers I think. (with backups in place obviously)
Has anyone attempted or know of any MS literature that advises against doing the upgrade on with such a large content DB?