How can you efficiently determine if any of the items in a List don't inherit their security from the List?
You could use SPListItem.HasUniqueRoleAssignments but this would require iterating through all items in the List.
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Leading on from @tylerrrr07's answer, there's another overload of
GetItemsWithUniquePermissions which may be of use to you:
You could then avoid the potentially huge result set from running the method by using the following:
SPList.GetItemsWithUniquePermissions(1, false).Count == 1