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With chrome, when I click on a KeePass document (a file with extension “.kdbx”), the file is downloaded into the download's folder.
Is it possible to open the file like any office document? I would like that changes to the document made directly to SharePoint without upload the file manually
Only if there is a server-side file handler to do so. SharePoint does not have support for that format out of the box; you'd have to see if a 3rd party provided support.