I've taken over as 'Admin' of an online SharePoint site in Office 365 with no background in SP administration. It's been requested that we enable multi-factor authentication (MFA) for only one site collection within our site. Does anyone know if this is possible, and if so, can you point me towards documentation on how to set it up? Based on my research, it is only possible to activate MFA per user for the whole O365 instance. https://social.technet.microsoft.com/wiki/contents/articles/36857.sharepoint-online-o365-set-up-multi-factor-authentication.aspx

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    you can't do MFA on a single site collection. Only on the tenant or MS account itself – Michael Colbs Nov 6 '17 at 20:55
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    @Colbs please put this as an answer as it is the correct answer. – Trevor Seward Nov 7 '17 at 15:54

You can't set Multi Factor Authentication per Site Collection, only on the tenant or the Microsoft account itself

Here is a technet article describing the process:


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Actually, with some customization, it is possible o have a single site OR just a library enforce MFA. We had that done for our Sharepoint online install. I am not the technologist to ask on "how", but it certainly is possible

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