We have multi server SharePoint 2016 farm which consist of 2 WFE, 1 APP, 1 Search and 1 DB. SharePoint Home page (publishing pages with variations) takes longer time to open when request is pass through one of WFE. All installation has been done through Min role and status is compliant. Some of ULS and even logs:
The program w3wp.exe, with the assigned process ID 8444, could not authenticate locally by using the target name HTTP/portal.com The target name used is not valid. A target name should refer to one of the local computer names, for example, the DNS host name. Try a different target name.
0x4224 SharePoint Foundation User Key
ayswe Unexpected Could not get SPWeb so could not get user key. 348dd59d-4baf-80d5-28a6-d323168488d4
There were logs related to Distributed cache too.