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enter image description herewe have intranet web application and deployed farm solutions, when we open any farm solution pages that resides n _layouts/eservices/empquery.aspx sometimes pages opened and get the data from sql and some times when we refresh or click again the same page it show below error.

The assembly 'C:\Windows\Microsoft.NET\Framework64\v2.0.50727\Temporary ASP.NET Files\root\bf3fce1a\adf83866\App_GlobalResources.dll' is already loaded in another appdomain. Setting <deployment retail="true" /> in machine.config can help solve this issue. Description: An unhandled exception occurred during the execution of the current web request. Please review the stack trace for more information about the error and where it originated in the code.

Exception Details: System.Web.HttpException: The assembly 'C:\Windows\Microsoft.NET\Framework64\v2.0.50727\Temporary ASP.NET Files\root\bf3fce1a\adf83866\App_GlobalResources.dll' is already loaded in another appdomain. Setting <deployment retail="true" /> in machine.config can help solve this issue.

Note: we disable debug=false in web .config and at machine level

<deployment retail="true" /> Event code: 3005 Event message: An unhandled exception has occurred. Event time: 23/11/1437 02:16:17 ص Event time (UTC): 22/11/1437 11:16:17 م Event ID: 8663b1247e284146bc926815058403cb Event sequence: 77 Event occurrence: 1 Event detail code: 0 Application information: Application domain: /LM/W3SVC/838794701/ROOT-11-131166405578384075 Trust level: WSS_Minimal Application Virtual Path: / Application Path: C:\inetpub\wwwroot\wss\VirtualDirectories\80\ Machine name: XXXXSPDV01 Process information: Process ID: 6204 Process name: w3wp.exe Account name: XXXX\spfarm Exception information: Exception type: HttpException Exception message: The assembly 'C:\Windows\Microsoft.NET\Framework64\v2.0.50727\Temporary ASP.NET Files\root\bf3fce1a\adf83866\App_GlobalResources.dll' is already loaded in another appdomain. Setting in machine.config can help solve this issue. Request information: Request URL: http://extranet.xxxx.xxxx/Style Library/images/fonts/gesstextlight-light.ttf Request path: /Style Library/images/fonts/gesstextlight-light.ttf User host address: 10.179.5.4 User:
Is authenticated: False Authentication Type:
Thread account name: XXXX\spfarm Thread information: Thread ID: 18 Thread account name: XXXX\spfarm Is impersonating: False Stack trace: at System.Web.Compilation.BuildManager.ReportTopLevelCompilationException() at System.Web.Compilation.BuildManager.EnsureTopLevelFilesCompiled()
at System.Web.Compilation.BuildManager.CallAppInitializeMethod() at System.Web.Hosting.HostingEnvironment.Initialize(ApplicationManager appManager, IApplicationHost appHost, IConfigMapPathFactory configMapPathFactory, HostingEnvironmentParameters hostingParameters)

Custom event details:

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