They aren't traditional controls per sé, like on a Windows Form, so there isn't an easy way to disable them, i.e. greyed out and not usable. If it would be sufficient to remove them from the DOM (not visible on the page therefore the user can't interact with them), using jQuery:
$( document ).ready(function() {
$("span#Ribbon.EditingTools.CPEditTab.Font-Medium-0-2-0.ms-cui-strip").hide();
});
Usually it's best to put that in a <script>
block just before the body tag closes.
If you want them to appear greyed out and not be clickable, you would need to target potentially hundreds of nested elements and alter the colouring of the A, the pen, the strip of colour on the button etc.
Edit: if you really want it to look and act "disabled" I can come up with some code lines that would achieve such.