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I'm using SharePoint 2010 and MS Office 2013 up until recently I was having no issues with this combination. Starting over the last week all MS Office documents will not open. The MS Office application will do 1 of 3 things:

  1. Run the launch window with "opening wfeserver/library/document.docx" until the user kills the program

  2. Open the program and go to a Not Responding state until the user kills the program

  3. Prompt the user with:

    sorry, we cannot open wfeserver/library/document.docx server isn't responding

So far, the only solution I found was to restart the IIS server on the WFE. I'm looking for what is causing this issue. is there a service or application pool that deals directly with MS Office files? Any ideas?

Note: Central Admin is running off another server. Central Admin doesn't experience the same issue only the sites on the WFE server. Also, this only affects MS Office files.

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start task manager, and end-task called MSOSYNC.EXE

  • 2
    This was something affecting all users at the same time not just a handful at different times. What I did to resolve the issue was set a IIS to refresh its connections every 2 hours. – Woodsy Feb 1 '16 at 20:44

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