I do a lot of testing with SharePoint 2010 across a few different browsers, regardless of which one I use (IE7, IE8 or FireFox) eventually I run into a problem where a page does not load or behaves incorrectly. To resolve the issue it usually requires me to clear cache and cookies. Is this something that others have noticed while sites are being built and customized? I find this happens a lot with JavaScript, where scripts are cached and if I haven't been using a particular browser recently I can go into a page and find all sorts of issues; luckily Firebug and DevTools help me out.
I am not sure if its IE or FireFox or SharePoint, or a combination, that generate this problem. Once we go live I wouldn't want to have Users complain about pages not working, and then have to tell them "oh, just clear your cache...". I do use FireBug on FireFox and Developer Tools on IE to help determine issues, which also allow me to clear cache easily, but I don't think this is good long term.
As a side note, we used to have BlobCache turned on, but turned that off due to other issues we were having with Authentication and Machine Keys.