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you have to create sharepoint workflow (using sharepoint designer) which starts when item is created in this list , this workflow will send an e-mail to the "Assigned to" user
check this link to find more info. about sending email in a workflow
http://office.microsoft.com/en-001/sharepoint-designer-help/send-e-mail-in-a-workflow-HA010239042.aspx
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For 2010, use the REST interface http://msdn.microsoft.com/en-us/library/ff798339.aspx
What will you be using to access the list? C#, Javascript ... ?
Some examples
http://weblogs.asp.net/paulballard/archive/2005/05/08/Using-Data-From-SharePoint-2003-Lists.aspx
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Maybe I'm thinking too much like a dev and not enough like someone looking for the simplest solution available, but it seems to me that you want to create an event receiver that operates on the list when the ItemAdded trigger is pulled. Here is a guide on how to set up an event receiver for a specific list instance:
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