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It is not possible. You need Microsoft SQL Server. More info in Hardware and software requirements for SharePoint 2013. Technet.


It is not possible to run it using MySQL server. You can use express edition for simple tasks but if your databases go more than 4GB I suggest you use many web apps instead (divide the work). For big companies it will be impossible to use SQL express edition so you would have to buy SQL Server. MySQL is not an available solution.

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