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I have around 300,000 users in the site collection and around 250 groups in the same site collection. When I am trying to open any group to get users in it. It is taking so long and finally it is showing "Request time out". another than that.... site collection is working fine.

How can open groups normally with out delay?

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Sounds like it is time to reduce the number of users in your SharePoint groups. Have you looked at using AD security groups instead of naming each user individually?

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