When I try to edit an word (2010) document from Sharepoint (2010) it takes ages to open (~5 minutes for a 3mb file). If I just copy it to my desktop and open it from there, it's lightning fast. The behavior is the same whether I try to open it from the web ui or from the explorer view.
I open up fiddler to check what was going on behind the scenes and saw some really strange stuff. First of all I'm getting several 401 - unauthorized responses. I'm not sure why - I have the right permissions to the file - but it could have something to do that we recently migrated all the users to a new domain. But then follows something even more odd - a couple of requests for dll-files, that are supposed to be on my sharepoint server! See this screen dump:
Have anyone seen this behavior before?