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Yeap, I swear I did not change any settings in the IE. About an hour ago I was able to click on a PDF in a document library and IE rendered it find. Now I get a dialog box asking me how do I want to open the item. "Check out & Open", "Open" or "Cancel".

File association looks good. Library settings looks good. Please suggest.

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Is this the same library? I'm wondering if you had different permissions on the other first one or perhaps it was checked out by another user at the time. – Dave Wise Apr 10 '13 at 20:04
Did somebody perhaps change the default file open behavior options? – Mike Oryszak Apr 10 '13 at 20:10
Is this acting the same on other computers? – Garrett Apr 10 '13 at 21:32

If you have access to Central Admin, you can check about how SharePoint serves up your documents. It sounds like something happened with the Browser File Handling setting in the Web Application General Setting ribbon command on the Manage Web Applications page.

Please refer to this question.

Edit: please also consider the security considerations brought up in this question before allowing all files to be handled permissively!

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