I've done a fair amount of looking into this idea without promising leads.
Let me define my problem:
I need to add a third column (as a Web Part Zone) to the "My Newsfeed" page in My Sites. The problem is SharePoint Designer will not be available (which comprises 90%+ of the solutions I've found for this problem) and I do not have access to the master page... which limits me to say the least.
Here's what I've dug up so far:
Now, it appears that in order for the page to persist the web part zone I can't just add it willy-nilly ( Using C# ) and it must be added before the PreInit() event in the page cycle (if added programmatically) on every request ( Addressing Page Cycle ) and the recommended method is by altering the code on the page to include an additional
asp:ContentPlaceHolder tag ( hence all, the SharePoint, Designer solutions ).
I'd like to do this via PowerShell once if possible (a la this link was trying to do-ish). Does anyone have suggestions on this?