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I have installed SP 2007 where nine domains are being hosted. Everything has been working correct until now. Right now, some of the domains cannot be displayed. I tried to edit the site in designer but I'm getting an error: Default.aspx cannot be found.

Only Central administration site and one of the domains ( are working correctly. IIS configuration looks fine, virtual directories are set correctly. What could happened? How can I fix it?

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Did you check the host header of the sites in IIS? did u do an IISReset? can u give more info on the error you are receiving since there could be possibly many reason for this? –  Deepu Nair Mar 22 '12 at 8:48
Everything has been working correct. Host Headers looks fine and I did IISReset. –  porterneon Mar 22 '12 at 9:07
How about authentication? Is it windows auth enabled? can u check that in IIS? –  Deepu Nair Mar 22 '12 at 11:27
Windows auth is enabled. Anonymous acces ans basic auth are disabled –  porterneon Mar 28 '12 at 11:09

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