When I try to edit My Site in SharePoint Designer I get the following:

So I have gone into Central Admin. Gone to my web application and have checked the SharePoint Designer section

All looks good.
Under Authentication I have Client Integration checked.

In Site Collection Administration for the site I have the following for SharePoint Designer Settings.

I have also performed an iisreset on the central admin server.
The user account I am using is a Site Collection Administrator.
What else could be wrong?