I had a clean environment prior to installing service pack 1 and the June CUs. User Profile Sync is up and running, and synchronizing, but all web applications are throwing a SharePoint error. Digging into the logs, we're getting "Exception occurred while connecting to WCF endpoint" claiming the connection request to ProfilePropertyService.svc exceeded the allotted timeout of 00:00:20. If I hit ProfilePropertyService.svc manually I get "The server was unable to process the request due to an internal error."
I have tried blowing away UPS, rebooting, rebuilding UPS and rebooting, and that did not resolve the issue. All services are started, and all application pools are online.